Short Communication The Buerger’s Disease and the Cryoglobulinemia, the Same Old Love?
by Mancuso Gaia*
Department of Internal Medicine, “Charity” Hospital of Locarno, Switzerland
*Corresponding author: Mancuso Gaia, Service of Immunology, Department of Internal Medicine, EOC, “Charity” Hospital of Locarno, Switzerland
Received Date: 12 August, 2024
Accepted Date: 21 August, 2024
Published Date: 23 August, 2024
Citation: Gaia M (2024) The Buerger’s Disease and the Cryoglobulinemia, the Same Old Love? J Orthop Res Ther 9: 1357. https://doi.org/10.29011/2575-8241.001357
Abstract
Thromboangiitis obliterans, also called Buerger disease, an uncommon cause of vasculitis, is a nonatherosclerotic, segmental, inflammatory disease that affects the small to medium-sized arteries and veins of the extremities (upper and lower) and, less commonly, cerebral/visceral vessels.
Type I cryoglobulinemia accounts for 10%-15% of patients with cryoglobulinemia. The type I cryoglobulinemia vasculitis is considered a life-threatening disorder because of the severity of cutaneous and renal involvement and the underlying hemopathy and even a limited quantity of paraproteins can cause severe symptoms.
We describe a 53-year-old women heavy cigarette smoker seen for extremity pain, claudication, recent complicated Raynaud phenomena. She had a type I cryoglobulinemia while the other laboratory tests were normal a bone marrow histology reveal a specific change. A causal relationship between TAO and cryoglobulinemia could not be proved and we suppose that the relationship between these two entities may be the expression of a unique dysregulation of type III hypersensitivity reaction.